Combined oral contraceptives, venous thromboembolism, and the problem of interpreting large but incomplete datasets.

Use of combined oral contraceptives and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases

OBJECTIVE To investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account. DESIGN Two nested case-control studies. SETTING General practices in the United Kingdom contributing to the Clinical Practice Research Datalink (CPRD; 618 practices) and QResearch primary care database (722 practices). PARTIC...

CPMP PUBLIC ASSESSMENT REPORT Combined oral contraceptives and venous thromboembolism

Effect of 1995 pill scare on rates of venous thromboembolism among women taking combined oral contraceptives: analysis of general practice research database.

OBJECTIVE To compare the incidence of venous thromboembolism among women taking combined oral contraceptives before and after the October 1995 pill scare. DESIGN Analysis of General Practice Research Database. SETTING United Kingdom, January 1993 to December 1998. SUBJECTS Women aged 15-49 taking combined oral contraceptives. MAIN OUTCOME MEASURES Incidence of venous thromboembolism. ...

Risk of venous thromboembolism in women with polycystic ovary syndrome: a population-based matched cohort analysis.

BACKGROUND There is an increased risk of venous thromboembolism among women taking oral contraceptives. However, whether there is an additional risk among women with polycystic ovary syndrome (PCOS) is unknown. METHODS We developed a population-based cohort from the IMS LifeLink Health Plan Claims Database, which includes managed care organizations in the United States. Women aged 18-46 years...

Risk of venous thromboembolism with oral contraceptives.

E1278 CMAJ, December 13, 2011, 183(18) © 2011 Canadian Medical Association or its licensors The lifetime incidence of venous thromboembolism for both men and women is estimated at 1 per 1000. Increasing our understanding of the precipitating risk factors, as well as optimizing the prevention of this condition in high-risk populations, could help to reduce the burden of venous thromboembolism. A...